Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study
Taichung Veterans General Hospital · Taipei Veterans General Hospital · +8 more institutions
Abstract
Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma. This population-based study aimed to investigate whether prevention of hepatocellular carcinoma by the universal Taiwanese HBV vaccine program, launched in July 1984, has extended beyond childhood and to identify the predictors of hepatocellular carcinoma for vaccinated birth cohorts.
Data on 1958 patients with hepatocellular carcinoma who were aged 6-29 years at diagnosis in Taiwan between 1983 and 2004 were collected from two national hepatocellular carcinoma registries. Age- and sex-specific incidence among vaccinated and unvaccinated birth cohorts were analyzed by using Poisson regression models. All statistical tests were two-sided. Records of 64 hepatocellular carcinoma patients and 5 524 435 HBV vaccinees who were born after the initiation of the vaccination program were compared for HBV immunization characteristics during infancy and prenatal maternal hepatitis B surface antigen (HBsAg) and e antigen (HBeAg) serostatus.
Citation impact
- FWCI
- 28.02
- Percentile
- 100%
- References
- 28
Authors
12- MCMei‐Hwei ChangCorresponding
Taichung Veterans General Hospital, Taipei Veterans General Hospital, Tri-Service General Hospital, Center for Disease Control, Kaohsiung Chang Gung Memorial Hospital, Chang Gung Memorial Hospital, Genomics Research Center, Academia Sinica, Chang Gung University, Ministry of Health and Welfare, National Taiwan University
- SYSan‐Lin You
Taichung Veterans General Hospital, Chang Gung University, Tri-Service General Hospital, National Taiwan University, Center for Disease Control, Taipei Veterans General Hospital, Kaohsiung Chang Gung Memorial Hospital, Chang Gung Memorial Hospital, Genomics Research Center, Academia Sinica, Ministry of Health and Welfare
- CCChien‐Jen Chen
National Taiwan University, Taipei Veterans General Hospital, Center for Disease Control, Chang Gung University, Taichung Veterans General Hospital, Ministry of Health and Welfare, Kaohsiung Chang Gung Memorial Hospital, Tri-Service General Hospital, Chang Gung Memorial Hospital, Genomics Research Center, Academia Sinica
- CLChun‐Jen Liu
Taichung Veterans General Hospital, Chang Gung University, Taipei Veterans General Hospital, Center for Disease Control, Ministry of Health and Welfare, National Taiwan University, Kaohsiung Chang Gung Memorial Hospital, Genomics Research Center, Academia Sinica, Chang Gung Memorial Hospital, Tri-Service General Hospital
- CLChuan–Mo Lee
Chang Gung University, Taichung Veterans General Hospital, National Taiwan University, Taipei Veterans General Hospital, Center for Disease Control, Genomics Research Center, Academia Sinica, Kaohsiung Chang Gung Memorial Hospital, Chang Gung Memorial Hospital, Tri-Service General Hospital, Ministry of Health and Welfare
Topics & keywords
- Hepatocellular carcinoma
- Incidence (geometry)
- Medicine
- Virology
- Internal medicine
- Gastroenterology
- Physics
- Good health and well-being