Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival
Université Paris Cité · Délégation Paris 7 · +8 more institutions
Abstract
Anti-HLA antibodies hamper successful transplantation, and activation of the complement cascade is involved in antibody-mediated rejection. We investigated whether the complement-binding capacity of anti-HLA antibodies plays a role in kidney-allograft failure.
We enrolled patients who received kidney allografts at two transplantation centers in Paris between January 1, 2005, and January 1, 2011, in a population-based study. Patients were screened for the presence of circulating donor-specific anti-HLA antibodies and their complement-binding capacity. Graft injury phenotype and the time to kidney-allograft loss were assessed.
Citation impact
- FWCI
- 52.60
- Percentile
- 100%
- References
- 37
Authors
20- ALAlexandre LoupyCorresponding
Université Paris Cité, Délégation Paris 7, Inserm, Hôpital Saint-Louis, Assistance Publique – Hôpitaux de Paris, Délégation Paris 5
- CLCarmen Lefaucheur
Inserm, Hôpital Saint-Louis, Assistance Publique – Hôpitaux de Paris, Délégation Paris 7, Université Paris Cité
- DVDéwi Vernerey
Université Paris Cité, Hôpital Saint-Louis, Assistance Publique – Hôpitaux de Paris, Inserm, Délégation Paris 7
- CPChristof Prugger
Inserm, Université Paris Cité, Délégation Paris 7, Hôpital Saint-Louis, Assistance Publique – Hôpitaux de Paris
- JDJean–Paul Duong Van Huyen
Topics & keywords
- Medicine
- Antibody
- Complement system
- Kidney transplantation
- Human leukocyte antigen
- Immunology
- Transplantation
- Hazard ratio
- Good health and well-being