Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia
Massachusetts Institute of Technology · Beth Israel Deaconess Medical Center · +9 more institutions
Abstract
We examined the status of the neural network mediating the default mode of brain function, which typically exhibits greater activation during rest than during task, in patients in the early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia. During functional MRI, patients, relatives, and controls alternated between rest and performance of working memory (WM) tasks. As expected, controls exhibited task-related suppression of activation in the default network, including medial prefrontal cortex (MPFC) and posterior cingulate cortex/precuneus. Patients and relatives exhibited significantly reduced task-related suppression in MPFC, and these reductions remained after…
Citation impact
- FWCI
- 38.86
- Percentile
- 100%
- References
- 41
Authors
13- SWSusan Whitfield‐GabrieliCorresponding
Massachusetts Institute of Technology
- HWHeidi W. Thermenos
Beth Israel Deaconess Medical Center, Harvard University, Massachusetts Mental Health Center, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts Institute of Technology
- SMSnežana Milanović
Beth Israel Deaconess Medical Center, Harvard University, Massachusetts Mental Health Center, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts Institute of Technology
- MTMing T. Tsuang
University of California San Diego
- SVStephen V. Faraone
SUNY Upstate Medical University
Topics & keywords
- Default mode network
- Schizophrenia (object-oriented programming)
- Precuneus
- Prefrontal cortex
- Psychology
- Psychopathology
- Working memory
- First-degree relatives