Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia mechanisms, are usually performed with channels expressed in non myocytes, or with non-human myocytes. Differences between cell types and species affect results. Thus, an accurate model for the undiseased human ventricular action potential (AP) which reproduces a broad range of physiological behaviors is needed. Such a model requires extensive experimental data, but essential elements have been unavailable. Here, we develop a human ventricular AP model using new undiseased human ventricular data: Ca(2+) versus voltage dependent inactivation of L-type Ca(2+) current (I(CaL)); kinetics for the transient outward, rapid delayed…

• NS
  National Science Foundation

  Award: 0929633
• AH
  American Heart Association
• FL
  Fondation Leducq
• HS
  Hungarian Scientific Research Fund

  Award: OTKA CNK-77855
• NK
  Nemzeti Kutatási és Technológiai Hivatal
• NI
  National Institutes of Health
• NH
  National Heart, Lung, and Blood Institute

  Award: R01-HL049054
• DO
  Division of Chemical, Bioengineering, Environmental, and Transport Systems