Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(EADI), European Alzheimer's Disease Initiative; Lambert, Jean‐Charles; (GERAD), Genetic and Environmental Risk in Alzheimer's Disease; Ibrahim‐Verbaas, Carla A.; Harold, Denise; Naj, Adam C.; Sims, Rebecca; Bellenguez, Céline; Jun, Gyungah; DeStefano, Anita L.; Bis, Joshua C; Beecham, Gary W.; Grenier‐Boley, Benjamin; Russo, Giancarlo; Thornton‐Wells, Tricia A.; Jones, Nicola; Smith, Albert V.; Chouraki, Vincent; Thomas, Charlene; Ikram, M. Arfan; Zélénika, Diana; Vardarajan, Badri N.; Kamatani, Yoichiro; Lin, Chiao‐Feng; Gerrish, Amy; Schmidt, Helena; Kunkle, Brian W.; Dunstan, Melanie; Ruiz, Agustı́n; Bihoreau, Marie‐Thérèse; Choi, Seung‐Hoan; Reitz, Christiane; Pasquier, Florence; Hollingworth, Paul; Ramı́rez, Alfredo; Hanon, Olivier; Fitzpatrick, Annette L.; Buxbaum, Joseph D.; Campion, Dominique; Crane, Paul K.; Baldwin, Clinton T.; Becker, Tim; Guðnason, Vilmundur; Cruchaga, Carlos; Craig, David; Amin, Najaf; Berr, Claudine; Lopez, Oscar L; Jager, Philip L. De; Deramecourt, Vincent; Johnston, Janet; Evans, Denis A.; Lovestone, Simon; Letenneur, Luc; Morón, Francisco Jesús; Rubinsztein, David C.; Eiriksdottir, Gudny; Sleegers, Kristel; Goate, Alison; Fiévet, Nathalie; Huentelman, Matthew J.; Gill, Michael; Brown, Kristelle; Kamboh, M. Ilyas; Keller, Lina; Barberger‐Gateau, Pascale; McGuinness, Bernadette; Larson, Eric B.; Green, Robert C.; Myers, Amanda; Dufouil, Carole; Todd, Stephen; Wallon, David; Love, Seth; Rogaeva, Ekaterina; Gallacher, John; George‐Hyslop, Peter St; Clarimón, Jordi; Lleó, Alberto; Bayer, Anthony; Tsuang, Debby W.; Yu, Lei; Tsolaki, Magda; Bossù, Paola; Spalletta, Gianfranco; Proitsi, Petroula; Collinge, John; Sorbi, Sandro; Sánchez-García, Florentino; Fox, Nick C.; Hardy, John; Naranjo, María Cándida Déniz; Bosco, Paolo; Clarke, Robert; Brayne, Carol; Galimberti, Daniela; Mancuso, Michelangelo; Matthews, Fiona E.; Moebus, Susanne; Mecocci, Patrizia; Zompo, Maria Del; Maier, Wolfgang; Hampel, Harald; Pilotto, Alberto; Bullido, María J.; Panza, Francesco; Caffarra, Paolo; Nacmias, Benedetta; Gilbert, John R.; Mayhaus, Manuel; Lannfelt, Lars; Håkonarson, Håkon; Pichler, Sabrina; Carrasquillo, Minerva M.; Ingelsson, Martin; Beekly, Duane; Álvarez, Victoria; Zou, Fanggeng; Valladares, Otto; Younkin, Steven G.; Coto, Eliécer; Hamilton‐Nelson, Kara L.; Gu, Wei; Razquín, Cristina; Pástor, Pau; Mateo, Ignacio; Owen, Michael J.; Faber, Kelley M.; Jónsson, Pálmi V.; Combarros, Onofre; O‘Donovan, Michael; Cantwell, Laura B.; Soininen, Hilkka; Blacker, Deborah; Mead, Simon; Mosley, Thomas H.; Bennett, David; Harris, Tamara B.; Fratiglioni, Laura; Holmes, Clive; Bruijn, Renée F.A.G. de; Passmore, Peter; Montine, Thomas J.; Bettens, Karolien; Rotter, Jerome I.; Brice, Alexis; Morgan, Kevin; Foroud, Tatiana; Kukull, Walter A.; Hannequin, Didier; Powell, John; Nalls, Michael A.; Ritchie, Karen; Lunetta, Kathryn L.; Kauwe, John S.K.; Boerwinkle, Eric; Riemenschneider, Matthias; Boada, Merçé; Hiltunen, Mikko; Martin, Eden R.; Schmidt, Reinhold; Rujescu, Dan; Wang, Li‐San; Dartigues, Jean‐François; Mayeux, Richard; Tzourio, Christophe; Hofman, Albert; Nöthen, Markus M.; Graff, Caroline; Psaty, Bruce M.; Jones, Lesley; Haines, Jonathan L.; Holmans, Peter; Lathrop, Mark; Pericak‐Vance, Margaret A.; Launer, Lenore J.; Farrer, Lindsay A.; Duijn, Cornelia M. van; Broeckhoven, Christine Van; Moskvina, Valentina; Seshadri, Sudha; Williams, Julie; Schellenberg, Gerard D.; Amouyel, Philippe

doi:10.1038/ng.2802

reviewNature GeneticsOct 27, 2013GREEN OA

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

EAEuropean Alzheimer's Disease Initiative (EADI)JLJean‐Charles LambertGAGenetic and Environmental Risk in Alzheimer's Disease (GERAD)CACarla A. Ibrahim‐Verbaas DHDenise Harold

Inserm · Université de Lille · +120 more institutions

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Abstract

No abstract available for this paper.

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Authors

184

EA
European Alzheimer's Disease Initiative (EADI)
Inserm
JL
Jean‐Charles Lambert
Inserm, Université de Lille, Institut Pasteur de Lille, Erasmus MC
GA
Genetic and Environmental Risk in Alzheimer's Disease (GERAD)
Cardiff University, Medical Research Council
CA
Carla A. Ibrahim‐Verbaas
Erasmus MC, University of Pennsylvania
DH
Denise Harold
Cardiff University, Medical Research Council

Topics & keywords

Topics

Keywords

Genome-wide association study
Single-nucleotide polymorphism
Apolipoprotein E
Disease
Biology
Alzheimer's disease
Genetic association
Genetics

UN Sustainable Development Goals

Good health and well-being

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