Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging

Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS function as "redox messengers" in intracellular signalling and regulation, whereas excess ROS induce cell death by promoting the intrinsic apoptotic pathway. Recent work has pointed to a further role of ROS in activation of autophagy and their importance in the regulation of aging. This review will focus on mitochondria as producers and targets of ROS and will summarize different proteins that modulate the redox state of the cell. Moreover, the involvement of ROS and mitochondria in different molecular pathways controlling lifespan will be…

• FI
  Fondazione Italiana Sclerosi Multipla
• FN
  Fundacja na rzecz Nauki Polskiej
• MD
  Ministero della Salute
• MD
  Ministero dell’Istruzione, dell’Università e della Ricerca
• AI
  Associazione Italiana per la Ricerca sul Cancro
• FI
  Fondazione Italiana per la Ricerca sul Cancro
• UD
  Università degli Studi di Ferrara
• FP
  Fondazione per la Ricerca sulla Fibrosi Cistica
• ER
  European Regional Development Fund