Analyses of pig genomes provide insight into porcine demography and evolution

For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast…

• UD
  U.S. Department of Agriculture
• IS
  Iowa State University
• WT
  Wellcome Trust
• IP
  Iowa Pork Producers Association
• NC
  North Carolina Pork Council
• SR
  Sight Research UK

  Awards: NE/F003382/2, NE/F003382/1, NE/H005269/1, NE/H005552/1
• IN
  Institut National de la Recherche Agronomique
• UO
  University of Illinois at Urbana-Champaign
• NI
  National Institute of Food and Agriculture
• CS
  Cooperative State Research, Education, and Extension Service
• AR
  Agricultural Research Service
• CO
  College of Agriculture and Life Sciences, Iowa State University
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/I025328/1, BBS/E/D/05191130, BB/E010768/1, BB/E011640/1, BB/E010520/1, BBS/E/D/20211550, BB/I025328/1, BBS/E/T/000PR5885, BB/H005935/1, BB/I025506/1, BB/E010520/2, BB/I025360/1, BB/E010520/2, BB/G004013/1, BB/E010520/1
• NE
  Natural Environment Research Council

  Awards: NE/F003382/2, NE/F003382/1, NE/H005552/1, NE/H005269/1
• NH
  National Health and Medical Research Council
• CO
  College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign