Chronic Kidney Disease as a Risk Factor for Cardiovascular Disease and All-Cause Mortality

Chronic kidney disease (CKD) is a major public health problem. Conflicting evidence exists among community-based studies as to whether CKD is an independent risk factor for adverse cardiovascular outcomes. After subjects with a baseline history of cardiovascular disease were excluded, data from four publicly available, community-based longitudinal studies were pooled: Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, Framingham Heart Study, and Framingham Offspring Study. Serum creatinine levels were indirectly calibrated across studies. CKD was defined by a GFR between 15 and 60 ml/min per 1.73 m(2). A composite of myocardial infarction, fatal coronary heart disease, stroke, and death…

• AS
  American Society of Nephrology
• A
  Amgen
• NH
  National Heart, Lung, and Blood Institute
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases