Fibrotic extracellular matrix activates a profibrotic positive feedback loop
Twin Cities Orthopedics · University of Minnesota · +3 more institutions
Abstract
Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive fibrotic scarring in the lung that ultimately leads to asphyxiation; however, the cascade of events that promote IPF are not well defined. Here, we examined how the interplay between the ECM and fibroblasts affects both the transcriptome and translatome by culturing primary fibroblasts generated from IPF patient lung tissue or nonfibrotic lung tissue on decellularized lung ECM from either IPF or control patients. Surprisingly, the origin of the ECM had a greater impact on gene expression than did cell origin, and differences in…
Citation impact
- FWCI
- 33.93
- Percentile
- 100%
- References
- 64
Authors
10- MWMatthew W. ParkerCorresponding
Twin Cities Orthopedics, University of Minnesota, Karolinska Institutet
- DRDaniel Rossi
Twin Cities Orthopedics, University of Minnesota
- MSMark S. Peterson
University of Minnesota, Twin Cities Orthopedics
- KSKaren Smith
University of Minnesota, Twin Cities Orthopedics
- KSKristina Sikström
Karolinska Institutet
Topics & keywords
- Extracellular matrix
- Idiopathic pulmonary fibrosis
- Cell biology
- Fibrosis
- Decellularization
- Transcriptome
- Biology
- Cancer research
- Good health and well-being