Abstract
Sleep and the circadian system exert a strong regulatory influence on immune functions. Investigations of the normal sleep-wake cycle showed that immune parameters like numbers of undifferentiated naïve T cells and the production of pro-inflammatory cytokines exhibit peaks during early nocturnal sleep whereas circulating numbers of immune cells with immediate effector functions, like cytotoxic natural killer cells, as well as anti-inflammatory cytokine activity peak during daytime wakefulness. Although it is difficult to entirely dissect the influence of sleep from that of the circadian rhythm, comparisons of the effects of nocturnal sleep with those of 24-h periods of wakefulness suggest that sleep…
Citation impact
1,104
total citations
- FWCI
- 8.81
- Percentile
- 100%
- References
- 133
Citations per year
Authors
3Topics & keywords
Topics
Keywords
- Immune system
- Circadian rhythm
- Sleep (system call)
- Wakefulness
- Cytotoxic T cell
- Immunology
- Sleep deprivation
- Endocrinology
UN Sustainable Development Goals
- Good health and well-being
No related works found for this paper.