Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
University of California, San Diego · Scripps Research Institute · +6 more institutions
Abstract
Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Hepcidin, a small peptide synthesized in the liver, is a key regulator of iron absorption and homeostasis in mammals. Hepcidin production is increased by iron overload and decreased by anemia and hypoxia; but the molecular mechanisms that govern the hepcidin response to these stimuli are not known. Here we establish that the von Hippel-Lindau/hypoxia-inducible transcription factor (VHL/HIF) pathway is an essential link between iron homeostasis and hepcidin regulation in vivo. Through coordinate downregulation of hepcidin and upregulation of erythropoietin and ferroportin, the VHL-HIF pathway…
Citation impact
- FWCI
- 24.74
- Percentile
- 100%
- References
- 37
Authors
8- CPCarole PeyssonnauxCorresponding
University of California, San Diego
- ASAnnelies S. Zinkernagel
University of California, San Diego
- RAReto A. Schuepbach
Scripps Research Institute
- EBErinn B. Rankin
University of Pennsylvania
- SVSophie Vaulont
Inserm, Institut Cochin, Centre National de la Recherche Scientifique, Délégation Paris 5, Université Paris Cité
Topics & keywords
- Hepcidin
- Downregulation and upregulation
- Erythropoietin
- Ferroportin
- Transcription factor
- Hypoxia (environmental)
- Hypoxia-inducible factors
- Erythropoiesis
- Clean water and sanitation