Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
Cancer Genetics (United States) · Herbert Irving Comprehensive Cancer Center · +12 more institutions
Abstract
The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is still largely unknown. The full spectrum of genetic lesions that are present in the CLL genome, and therefore the number and identity of dysregulated cellular pathways, have not been identified. By combining next-generation sequencing and copy number analysis, we show here that the typical CLL coding genome contains
Citation impact
- FWCI
- 38.06
- Percentile
- 100%
- References
- 70
Authors
28- GFGiulia FabbriCorresponding
Cancer Genetics (United States), Herbert Irving Comprehensive Cancer Center, Columbia University
- SRSilvia Rasi
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
- DRDavide Rossi
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
- ВТВладимир Трифонов
Cancer Genetics (United States), Herbert Irving Comprehensive Cancer Center, Columbia University
- HKHossein Khiabanian
Cancer Genetics (United States), Herbert Irving Comprehensive Cancer Center, Columbia University
Topics & keywords
- Chronic lymphocytic leukemia
- Leukemia
- Biology
- Gene
- Genome
- Genetics
- Cancer research
- No poverty