Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
University of Dental Medicine · University at Buffalo, State University of New York · +2 more institutions
Abstract
The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although disseminated, vaginal, and oral candidiasis are all caused by C. albicans species, host defense against C. albicans varies by anatomical location. T helper 1 (Th1) cells have long been implicated in defense against candidiasis, whereas the role of Th17 cells remains controversial. IL-17 mediates inflammatory pathology in a gastric model of mucosal candidiasis, but is host protective in disseminated disease. Here, we directly compared Th1 and Th17 function in a model of OPC. Th17-deficient (IL-23p19(-/-)) and IL-17R-deficient (IL-17RA(-/-)) mice experienced severe OPC, whereas…
Citation impact
- FWCI
- 43.15
- Percentile
- 100%
- References
- 78
Authors
14- HRHeather R. Conti
University of Dental Medicine, University at Buffalo, State University of New York
- FSFang Shen
University of Dental Medicine, University at Buffalo, State University of New York
- NNNamrata Nayyar
University of Dental Medicine, University at Buffalo, State University of New York
- ESEileen Stocum
University of Dental Medicine, University at Buffalo, State University of New York
- JNJianing N. Sun
University of Dental Medicine, University at Buffalo, State University of New York
Topics & keywords
- Host (biology)
- Receptor
- Immunology
- Signal transduction
- Microbiology
- Biology
- Cell biology
- Ecology