articleDiabetesJul 1, 2003BRONZE OA

Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes

BBBruce Bartholow DuncanMIMaría Inês SchmidtJSJames S. PankowCMChristie M. BallantyneDCDavid Couper

University of North Carolina at Chapel Hill · Universidade Federal do Rio Grande do Sul · +2 more institutions

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Abstract

To examine the association of low-grade systemic inflammation with diabetes, as well as its heterogeneity across subgroups, we designed a case-cohort study representing the approximately 9-year experience of 10,275 Atherosclerosis Risk in Communities Study participants. Analytes were measured on stored plasma of 581 incident cases of diabetes and 572 noncases. Statistically significant hazard ratios of developing diabetes for those in the fourth (versus first) quartile of inflammation markers, adjusted for age, sex, ethnicity, study center, parental history of diabetes, and hypertension, ranged from 1.9 to 2.8 for sialic acid, orosomucoid, interleukin-6, and C-reactive protein. After additional adjustment for…

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Topics & keywords

Topics
Keywords
  • Medicine
  • Diabetes mellitus
  • Internal medicine
  • Hazard ratio
  • Type 2 diabetes
  • Orosomucoid
  • Quartile
  • Inflammation
UN Sustainable Development Goals
  • Good health and well-being
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