The Challenge of Finding a Cure for HIV Infection
University of North Carolina at Chapel Hill · Gladstone Institutes · +3 more institutions
Abstract
Although combination therapy for HIV infection represents a triumph for modern medicine, chronic suppressive therapy is required to contain persistent infection in reservoirs such as latently infected CD4+ lymphocytes and cells of the macrophage-monocyte lineage. Despite its success, chronic suppressive therapy is limited by its cost, the requirement of lifelong adherence, and the unknown effects of long-term treatment. This review discusses our current understanding of suppressive antiretroviral therapy, the latent viral reservoir, and the needs for and challenges of attacking this reservoir to achieve a cure.
Citation impact
- FWCI
- 29.44
- Percentile
- 100%
- References
- 50
Authors
6- DDDouglas D. RichmanCorresponding
University of North Carolina at Chapel Hill, Gladstone Institutes, United States Military Academy, VA San Diego Healthcare System, Mission Bio (United States)
- DMDavid M. Margolis
University of North Carolina at Chapel Hill, Gladstone Institutes, United States Military Academy, VA San Diego Healthcare System, Mission Bio (United States)
- MDMartin DelaneyCorresponding
University of North Carolina at Chapel Hill, Gladstone Institutes, United States Military Academy, VA San Diego Healthcare System, Mission Bio (United States)
- WCWarner C. Greene
University of North Carolina at Chapel Hill, Gladstone Institutes, United States Military Academy, VA San Diego Healthcare System, Mission Bio (United States)
- DJDaria J. Hazuda
University of North Carolina at Chapel Hill, Gladstone Institutes, United States Military Academy, VA San Diego Healthcare System, Mission Bio (United States)
Topics & keywords
- Antiretroviral therapy
- Human immunodeficiency virus (HIV)
- Immunology
- Medicine
- Intensive care medicine
- Lineage (genetic)
- Virology
- Biology
- Good health and well-being