Sex differences in human adipose tissues – the biology of pear shape
Boston University · Sanford Burnham Prebys Medical Discovery Institute · +2 more institutions
Abstract
Women have more body fat than men, but in contrast to the deleterious metabolic consequences of the central obesity typical of men, the pear-shaped body fat distribution of many women is associated with lower cardiometabolic risk. To understand the mechanisms regulating adiposity and adipose tissue distribution in men and women, significant research attention has focused on comparing adipocyte morphological and metabolic properties, as well as the capacity of preadipocytes derived from different depots for proliferation and differentiation. Available evidence points to possible intrinsic, cell autonomous differences in preadipocytes and adipocytes, as well as modulatory roles for sex steroids, the…
Citation impact
- FWCI
- 12.46
- Percentile
- 100%
- References
- 184
Authors
4Topics & keywords
- Adipose tissue
- Adipokine
- Obesity
- Endocrinology
- Internal medicine
- Adipocyte
- Adipogenesis
- Biology