articleProceedings of the National Academy of SciencesMay 11, 2009GREEN OA

Antioxidants prevent health-promoting effects of physical exercise in humans

MRMichael RistowKZKim ZarseAOAndreas OberbachNKNora KlötingMBMarc Birringer

German Institute of Human Nutrition · Friedrich Schiller University Jena · +4 more institutions

PubMed
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Abstract

Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS). Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unknown. We evaluated the effects of a combination of vitamin C (1000 mg/day) and vitamin E (400 IU/day) on insulin sensitivity as measured by glucose infusion rates (GIR) during a hyperinsulinemic, euglycemic clamp in previously untrained (n = 19) and pretrained (n = 20) healthy young men. Before and after a 4 week intervention of physical exercise, GIR was determined, and muscle biopsies for gene…

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Topics & keywords

Topics
Keywords
  • Internal medicine
  • Endocrinology
  • Oxidative stress
  • Insulin resistance
  • Adiponectin
  • Reactive oxygen species
  • Antioxidant
  • Vitamin E
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