T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension
Pompeu Fabra University · SIB Swiss Institute of Bioinformatics
Abstract
This article introduces a new interface for T-Coffee, a consistency-based multiple sequence alignment program. This interface provides an easy and intuitive access to the most popular functionality of the package. These include the default T-Coffee mode for protein and nucleic acid sequences, the M-Coffee mode that allows combining the output of any other aligners, and template-based modes of T-Coffee that deliver high accuracy alignments while using structural or homology derived templates. These three available template modes are Expresso for the alignment of protein with a known 3D-Structure, R-Coffee to align RNA sequences with conserved secondary structures and PSI-Coffee to accurately align distantly…
Citation impact
- FWCI
- 22.61
- Percentile
- 100%
- References
- 27
Authors
8- PDPaolo Di TommasoCorresponding
- SMSébastien Moretti
Pompeu Fabra University, SIB Swiss Institute of Bioinformatics
- IXIoannis Xénarios
Pompeu Fabra University, SIB Swiss Institute of Bioinformatics
- MOMiquel Orobitg
SIB Swiss Institute of Bioinformatics, Pompeu Fabra University
- AMA. Montanyola
SIB Swiss Institute of Bioinformatics, Pompeu Fabra University
Topics & keywords
- Biology
- Homology (biology)
- Template
- Sequence alignment
- Web server
- Computational biology
- Multiple sequence alignment
- Sequence homology