Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
University of Washington · University of California, Irvine · +2 more institutions
Abstract
To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria (MCAT). Median and maximum life spans were maximally increased (averages of 5 months and 5.5 months, respectively) in MCAT animals. Cardiac pathology and cataract development were delayed, oxidative damage was reduced, H2O2 production and H2O2-induced aconitase inactivation were attenuated, and the development of mitochondrial deletions was reduced. These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals.
Citation impact
- FWCI
- 47.25
- Percentile
- 100%
- References
- 19
Authors
12- SESamuel E. Schriner
University of Washington, University of California, Irvine, Cancer Research And Biostatistics
- NJNancy J. Linford
University of Washington, University of California, Irvine, Cancer Research And Biostatistics
- GMGeorge M. Martin
University of Washington, University of California, Irvine, Cancer Research And Biostatistics
- PMPiper M. Treuting
University of Washington, University of California, Irvine, Cancer Research And Biostatistics
- CECharles E. Ogburn
University of Washington, University of California, Irvine, Cancer Research And Biostatistics
Topics & keywords
- Catalase
- Life span
- Mitochondrion
- Extension (predicate logic)
- Span (engineering)
- Life extension
- Biology
- Cell biology