Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia
John Radcliffe Hospital · University of Oxford · +4 more institutions
Abstract
Adolescent-onset schizophrenia provides an exceptional opportunity to explore the neuropathology of schizophrenia free from the potential confounds of prolonged periods of medication and disease interactions with age-related neurodegeneration. Our aim was to investigate structural grey and white matter abnormalities in adolescent-onset schizophrenia. Whole-brain voxel-wise investigation of both grey matter topography and white matter integrity (Fractional Anisotropy) were carried out on 25 adolescent-onset schizophrenic patients and 25 healthy adolescents. We employed a refined voxel-based morphometry-like approach for grey matter analysis and the recently introduced method of tract-based spatial statistics…
Citation impact
- FWCI
- 17.44
- Percentile
- 100%
- References
- 134
Authors
11- GDGwenaëlle DouaudCorresponding
John Radcliffe Hospital, University of Oxford, Wellcome Centre for Integrative Neuroimaging
- SMStephen M. Smith
John Radcliffe Hospital, Imperial College London
- MJMark Jenkinson
Imperial College London, John Radcliffe Hospital
- TETimothy E.J. Behrens
Imperial College London, John Radcliffe Hospital
- HJHeidi Johansen‐Berg
Imperial College London, John Radcliffe Hospital
Topics & keywords
- Grey matter
- White matter
- Fractional anisotropy
- Corpus callosum
- Psychology
- Schizophrenia (object-oriented programming)
- Arcuate fasciculus
- Voxel-based morphometry
- Good health and well-being