Paraneoplastic Thrombocytosis in Ovarian Cancer
Queen Mary University of London · Centre for Cancer Biology · +10 more institutions
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Abstract
Background
The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear.
Methods
We analyzed clinical data on 619 patients with epithelial ovarian cancer to test associations between platelet counts and disease outcome. Human samples and mouse models of epithelial ovarian cancer were used to explore the underlying mechanisms of paraneoplastic thrombocytosis. The effects of platelets on tumor growth and angiogenesis were ascertained.
Citation impact
822
total citations
- FWCI
- 23.71
- Percentile
- 100%
- References
- 26
Citations per year
Authors
34Topics & keywords
Topics
Keywords
- Medicine
- Thrombocytosis
- Ovarian cancer
- Cancer
- Oncology
- Internal medicine
- Pathology
- Gynecology
UN Sustainable Development Goals
- Zero hunger
No related works found for this paper.
Funding
- UDU.S. Department of DefenseAwards: RC2GM092599, U54 CA151668, CA128797, BC085265, OC073399
- OCOvarian Cancer Research Fund
- RFRGK Foundation
- QMQueen Mary University of London
- LALaura and John Arnold FoundationAwards: BC085265, RC2GM092599, U54 CA151668, CA128797
- MFMarcus Foundation
- NINational Institutes of HealthAwards: CA009666, P50 CA083639, CA128797, CA083639, CA016672, T32 CA009666, U54 CA151668, CA109298, CA101642, CA098258, P50 CA098258, BC085265, T32 CA101642, RC2GM092599, CA140933
- MRMedical Research Council
- NCNational Cancer InstituteAwards: CA109298, T32 CA101642, CA016672, T32 CA009666, CA009666, CA140933, P50 CA098258, U54 CA151668, P50 CA083639, CA098258, CA101642