articlePLoS ONEAug 7, 2009GOLD OA

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

BQBin‐Zhi QianYDYan DengJHJae Hong ImRJRuth J. MuschelYZYiyu Zou

Albert Einstein College of Medicine · University of Oxford · +1 more institution

PubMed
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Abstract

BACKGROUND: The stromal microenvironment and particularly the macrophage component of primary tumors influence their malignant potential. However, at the metastatic site the role of these cells and their mechanism of actions for establishment and growth of metastases remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Using animal models of breast cancer metastasis, we show that a population of host macrophages displaying a distinct phenotype is recruited to extravasating pulmonary metastatic cells regardless of species of origin. Ablation of this macrophage population through three independent means (genetic and chemical) showed that these macrophages are required for efficient metastatic seeding and…

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Topics & keywords

Topics
Keywords
  • Extravasation
  • Metastatic breast cancer
  • Macrophage
  • Metastasis
  • Population
  • Stromal cell
  • Cancer research
  • Pathology
UN Sustainable Development Goals
  • Good health and well-being
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