Genome sequence of the model medicinal mushroom Ganoderma lucidum
Chinese Academy of Medical Sciences & Peking Union Medical College · Academy of Medical Sciences · +7 more institutions
Abstract
Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioactive compounds. Here we report its 43.3-Mb genome, encoding 16,113 predicted genes, obtained using next-generation sequencing and optical mapping approaches. The sequence analysis reveals an impressive array of genes encoding cytochrome P450s (CYPs), transporters and regulatory proteins that cooperate in secondary metabolism. The genome also encodes one of the richest sets of wood degradation enzymes among all of the sequenced basidiomycetes. In all, 24 physical CYP gene clusters are identified. Moreover, 78 CYP genes are coexpressed with lanosterol synthase, and 16 of these show high…
Citation impact
- FWCI
- 25.30
- Percentile
- 100%
- References
- 60
Authors
33- SCShilin ChenCorresponding
Chinese Academy of Medical Sciences & Peking Union Medical College
- JXJiang Xu
Chinese Academy of Medical Sciences & Peking Union Medical College, Academy of Medical Sciences
- CLChang Liu
Chinese Academy of Medical Sciences & Peking Union Medical College, Academy of Medical Sciences
- YZYingjie Zhu
Academy of Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College
- DRDavid R. Nelson
University of Tennessee Health Science Center
Topics & keywords
- Gene
- Lanosterol
- Genome
- Biology
- Medicinal fungi
- Computational biology
- Ganoderma
- Secondary metabolism
- Life in Land