articleThe Journal of Experimental MedicineJul 26, 2004BRONZE OA

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

MRMichael R. EhrensteinJGJ. Grimley EvansASAnimesh SinghSMSamantha MooreGWGary Warnes

University College London · Cancer Research UK

PubMed
Indexed incrossrefpubmed

Abstract

Regulatory T cells have been clearly implicated in the control of disease in murine models of autoimmunity. The paucity of data regarding the role of these lymphocytes in human autoimmune disease has prompted us to examine their function in patients with rheumatoid arthritis (RA). Regulatory (CD4(+)CD25(+)) T cells isolated from patients with active RA displayed an anergic phenotype upon stimulation with anti-CD3 and anti-CD28 antibodies, and suppressed the proliferation of effector T cells in vitro. However, they were unable to suppress proinflammatory cytokine secretion from activated T cells and monocytes, or to convey a suppressive phenotype to effector CD4(+)CD25(-) T cells. Treatment with antitumor…

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Topics & keywords

Topics
Keywords
  • IL-2 receptor
  • Immunology
  • Tumor necrosis factor alpha
  • Regulatory T cell
  • Proinflammatory cytokine
  • Cytokine
  • Autoimmunity
  • CD28
UN Sustainable Development Goals
  • Good health and well-being
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