Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells
Istituto Giannina Gaslini · University of Genoa
Abstract
The surface density of the triggering receptors responsible for the natural killer (NK)-mediated cytotoxicity is crucial for the ability of NK cells to kill susceptible target cells. In this study, we show that transforming growth factor beta1 (TGFbeta1) down-regulates the surface expression of NKp30 and in part of NKG2D but not that of other triggering receptors such as NKp46. The TGFbeta1-mediated inhibition of NKp30 surface expression reflects gene regulation at the transcriptional level. NKp30 has been shown to represent the major receptor involved in the NK-mediated killing of dendritic cells. Accordingly, the TGFbeta1-dependent down-regulation of NKp30 expression profoundly inhibited the NK-mediated…
Citation impact
- FWCI
- 7.92
- Percentile
- 100%
- References
- 35
Authors
10- RCRoberta Castriconi
Istituto Giannina Gaslini, University of Genoa
- CCClaudia Cantoni
Istituto Giannina Gaslini, University of Genoa
- MDMariella Della Chiesa
Istituto Giannina Gaslini, University of Genoa
- MVMassimo Vitale
Istituto Giannina Gaslini, University of Genoa
- EMEmanuela Marcenaro
Istituto Giannina Gaslini, University of Genoa
Topics & keywords
- NKG2D
- Cell biology
- Receptor
- Biology
- Transforming growth factor
- Interleukin 12
- Cytotoxicity
- Cytotoxic T cell