reviewAnnual Review of ImmunologyNov 11, 2004Closed access

IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors

YLYong-Jun Liu

The University of Texas MD Anderson Cancer Center

PubMed
Indexed incrossrefpubmed

Abstract

Type 1 interferon-(alpha, beta, omega)-producing cells (IPCs), also known as plasmacytoid dendritic cell precursors (pDCs), represent 0.2%-0.8% of peripheral blood mononuclear cells in both humans and mice. IPCs display plasma cell morphology, selectively express Toll-like receptor (TLR)-7 and TLR9, and are specialized in rapidly secreting massive amounts of type 1 interferon following viral stimulation. IPCs can promote the function of natural killer cells, B cells, T cells, and myeloid DCs through type 1 interferons during an antiviral immune response. At a later stage of viral infection, IPCs differentiate into a unique type of mature dendritic cell, which directly regulates the function of T cells and thus…

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Topics & keywords

Topics
Keywords
  • Biology
  • Plasmacytoid dendritic cell
  • Immunology
  • Interferon
  • Innate immune system
  • Immune system
  • Dendritic cell
  • Interferon type I
UN Sustainable Development Goals
  • Good health and well-being
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