Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors

Adiponectin is a fat-derived hormone with antidiabetic and antiatherogenic properties. Hypoadiponectinemia seen in obesity is associated with insulin-resistant diabetes and atherosclerosis. Thiazolidinediones, peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists, have been shown to increase plasma adiponectin levels by the transcriptional induction in adipose tissues. However, the precise mechanism of such action is unknown. In this study, we have identified a functional PPAR-responsive element (PPRE) in human adiponectin promoter. PPAR-gamma/retinoid X receptor (RXR) heterodimer directly bound to the PPRE and increased the promoter activity in cells. In adipocytes, point mutation of the PPRE…

• NF
  Naito Foundation
• SM
  Suzuken Memorial Foundation
• CS
  Cell Science Research Foundation
• NF
  Novartis Foundation
• JR
  Japan Research Foundation for Clinical Pharmacology
• MM
  Mochida Memorial Foundation for Medical and Pharmaceutical Research
• DS
  Daiwa Securities Health Foundation
• KF
  Kanae Foundation for the Promotion of Medical Science
• NF
  NOVARTIS Foundation (Japan) for the Promotion of Science
• JH
  Japan Heart Foundation