Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
Northwestern University · Rush University Medical Center
Abstract
The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-beta-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals. ADDL concentrations for the subjects diagnosed with AD were consistently higher than the levels in the CSF taken from nondemented age-matched controls. Studies of ADDLs or for any other potential pathogenic AD markers in CSF have not been possible because of their low concentration in CSF (
Citation impact
- FWCI
- 32.21
- Percentile
- 100%
- References
- 38
Authors
7- DGD.G. GeorganopoulouCorresponding
Northwestern University, Rush University Medical Center
- LCLei Chang
Northwestern University, Rush University Medical Center
- JNJwa‐Min Nam
Northwestern University, Rush University Medical Center
- CSC. Shad Thaxton
Northwestern University, Rush University Medical Center
- EJElliott J. Mufson
Northwestern University, Rush University Medical Center
Topics & keywords
- Cerebrospinal fluid
- Biomarker
- Cerebral Spinal Fluid
- Alzheimer's disease
- Disease
- Amyloid (mycology)
- Medicine
- Pathology
- Good health and well-being