Two-Photon Luminescence Imaging of Cancer Cells Using Molecularly Targeted Gold Nanorods
The University of Texas at Austin · The University of Texas MD Anderson Cancer Center
Abstract
We demonstrate the use of gold nanorods as bright contrast agents for two-photon luminescence (TPL) imaging of cancer cells in a three-dimensional tissue phantom down to 75 mum deep. The TPL intensity from gold-nanorod-labeled cancer cells is 3 orders of magnitude brighter than the two-photon autofluorescence (TPAF) emission intensity from unlabeled cancer cells at 760 nm excitation light. Their strong signal, resistance to photobleaching, chemical stability, ease of synthesis, simplicity of conjugation chemistry, and biocompatibility make gold nanorods an attractive contrast agent for two-photon imaging of epithelial cancer.
Citation impact
- FWCI
- 60.12
- Percentile
- 100%
- References
- 31
Authors
6- NJNicholas J. DurrCorresponding
The University of Texas at Austin, The University of Texas MD Anderson Cancer Center
- TLTimothy Larson
The University of Texas at Austin, The University of Texas MD Anderson Cancer Center
- DKDanielle K. Smith
The University of Texas MD Anderson Cancer Center, The University of Texas at Austin
- BABrian A. Korgel
The University of Texas MD Anderson Cancer Center, The University of Texas at Austin
- KSKonstantin Sokolov
The University of Texas MD Anderson Cancer Center, The University of Texas at Austin
Topics & keywords
- Nanorod
- Luminescence
- Two-photon excitation microscopy
- Nanotechnology
- Cancer imaging
- Materials science
- Cancer cell
- Optoelectronics