Effects of cannabinoids and cannabinoid‐enriched  Cannabis  extracts on TRP channels and endocannabinoid metabolic enzymes

Petrocellis, Luciano De; Ligresti, Alessia; Moriello, Aniello Schiano; Allarà, Marco; Bisogno, Tiziana; Petrosino, Stefania; Stott, Colin; Marzo, Vincenzo Di

doi:10.1111/j.1476-5381.2010.01166.x

articleBritish Journal of PharmacologyDec 22, 2010BRONZE OA

Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

LDLuciano De Petrocellis ALAlessia Ligresti ASAniello Schiano Moriello MAMarco Allarà TBTiziana Bisogno

Institute of Applied Science and Intelligent Systems · GW Pharmaceuticals (United Kingdom)

PubMed

Indexed incrossrefpubmed

Abstract

BACKGROUND AND PURPOSE: Cannabidiol (CBD) and Δ(9) -tetrahydrocannabinol (THC) interact with transient receptor potential (TRP) channels and enzymes of the endocannabinoid system. EXPERIMENTAL APPROACH: The effects of 11 pure cannabinoids and botanical extracts [botanical drug substance (BDS)] from Cannabis varieties selected to contain a more abundant cannabinoid, on TRPV1, TRPV2, TRPM8, TRPA1, human recombinant diacylglycerol lipase α (DAGLα), rat brain fatty acid amide hydrolase (FAAH), COS cell monoacylglycerol lipase (MAGL), human recombinant N-acylethanolamine acid amide hydrolase (NAAA) and anandamide cellular uptake (ACU) by RBL-2H3 cells, were studied using fluorescence-based calcium assays in…

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Topics & keywords

Topics

Keywords

Monoacylglycerol lipase
Fatty acid amide hydrolase
Cannabidiol
Endocannabinoid system
Anandamide
Chemistry
Cannabinoid
Pharmacology

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GW Pharmaceuticals