In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction
Johns Hopkins University · Bilkent University · +2 more institutions
Abstract
We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. METHODS AND RESULTS: Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16x107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals.
MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.
Citation impact
- FWCI
- 27.00
- Percentile
- 100%
- References
- 10
Authors
8- DLDara L. KraitchmanCorresponding
Johns Hopkins University, Bilkent University, Johns Hopkins Medicine, Osiris Therapeutics (United States)
- AWAlan W. Heldman
Johns Hopkins University, Bilkent University, Johns Hopkins Medicine, Osiris Therapeutics (United States)
- EAErgin Atalar
Johns Hopkins University, Bilkent University, Johns Hopkins Medicine, Osiris Therapeutics (United States)
- LCLuciano C. Amado
Johns Hopkins University, Bilkent University, Johns Hopkins Medicine, Osiris Therapeutics (United States)
- BJBradley J. Martin
Johns Hopkins University, Bilkent University, Johns Hopkins Medicine, Osiris Therapeutics (United States)
Topics & keywords
- Medicine
- Mesenchymal stem cell
- Magnetic resonance imaging
- In vivo
- Myocardial infarction
- Pathology
- Radiology
- Nuclear medicine