articleProceedings of the National Academy of SciencesOct 11, 2007GREEN OA

Evolution of adverse changes in stored RBCs

EBElliott Bennett‐GuerreroTHTim H. VeldmanADAllan DoctorMJMarilyn J. TelenTLThomas L. Ortel

Duke Medical Center · Washington University in St. Louis · +4 more institutions

PubMed
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Abstract

Recent studies have underscored questions about the balance of risk and benefit of RBC transfusion. A better understanding of the nature and timing of molecular and functional changes in stored RBCs may provide strategies to improve the balance of benefit and risk of RBC transfusion. We analyzed changes occurring during RBC storage focusing on RBC deformability, RBC-dependent vasoregulatory function, and S-nitrosohemoglobin (SNO-Hb), through which hemoglobin (Hb) O(2) desaturation is coupled to regional increases in blood flow in vivo (hypoxic vasodilation). Five hundred ml of blood from each of 15 healthy volunteers was processed into leukofiltered, additive solution 3-exposed RBCs and stored at 1-6 degrees C…

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11

Topics & keywords

Topics
Keywords
  • Erythrocyte deformability
  • Hemoglobin
  • Chemistry
  • Red blood cell
  • Vasodilation
  • Whole blood
  • Oxidative stress
  • Adverse effect
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