articleThe Journal of Toxicological SciencesJan 1, 2008BRONZE OA

Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube

ATAtsuya TakagiAHAkihiko HiroseTNTetsuji NishimuraNFNobutaka FukumoriAOAkio Ogata

National Institute of Health Sciences · Tokyo Metropolitan Institute of Public Health

PubMed
Indexed incrossrefpubmed

Abstract

Nanomaterials of carbon origin tend to form various shapes of particles in micrometer dimensions. Among them, multi-wall carbon nanotubes (MWCNT) form fibrous or rod-shaped particles of length around 10 to 20 micrometers with an aspect ratio of more than three. Fibrous particles of this dimension including asbestos and some man-made fibers are reported to be carcinogenic, typically inducing mesothelioma. Here we report that MWCNT induces mesothelioma along with a positive control, crocidolite (blue asbestos), when administered intraperitoneally to p53 heterozygous mice that have been reported to be sensitive to asbestos. Our results point out the possibility that carbon-made fibrous or rod-shaped micrometer…

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Topics & keywords

Topics
Keywords
  • Mesothelioma
  • Asbestos
  • Carbon nanotube
  • Nanomaterials
  • Nanotechnology
  • Carcinogen
  • Asbestos fibers
  • Micrometer
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