articleBloodApr 27, 2005BRONZE OA

Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance

SVS. Vincent RajkumarRARobert A. KyleTMTerry M. TherneauLJL. Joseph MeltonABA.R. Bradwell

Mayo Clinic · University of Birmingham

PubMed
Indexed incrossrefpubmed

Abstract

We hypothesized that the presence of monoclonal free kappa or lambda immunoglobulin light chains in monoclonal gammopathy of undetermined significance (MGUS), as detected by the serum free light chain (FLC) assay increases the risk of progression to malignancy. Of 1384 patients with MGUS from Southeastern Minnesota seen at the Mayo Clinic from 1960 to 1994, baseline serum samples obtained within 30 days of diagnosis were available in 1148. At a median follow-up of 15 years, malignant progression had occurred in 87 (7.6%) patients. An abnormal FLC ratio (kappa-lambda ratio 1.65) was detected in 379 (33%) patients. The risk of progression in patients with an abnormal FLC ratio was significantly higher compared…

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Topics & keywords

Topics
Keywords
  • Monoclonal gammopathy of undetermined significance
  • Hazard ratio
  • Immunoglobulin light chain
  • Medicine
  • Risk factor
  • Confidence interval
  • Internal medicine
  • Gastroenterology
UN Sustainable Development Goals
  • Good health and well-being
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