Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
National Institutes of Health · National Institute of Arthritis and Musculoskeletal and Skin Diseases · +3 more institutions
Abstract
Reactive oxygen species (ROS) have an established role in inflammation and host defense, as they kill intracellular bacteria and have been shown to activate the NLRP3 inflammasome. Here, we find that ROS generated by mitochondrial respiration are important for normal lipopolysaccharide (LPS)-driven production of several proinflammatory cytokines and for the enhanced responsiveness to LPS seen in cells from patients with tumor necrosis factor receptor-associated periodic syndrome (TRAPS), an autoinflammatory disorder caused by missense mutations in the type 1 TNF receptor (TNFR1). We find elevated baseline ROS in both mouse embryonic fibroblasts and human immune cells harboring TRAPS-associated TNFR1 mutations.…
Citation impact
- FWCI
- 31.39
- Percentile
- 100%
- References
- 67
Authors
9- ACAriel C. Bulua
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Autoimmune Technologies (United States), National Heart Lung and Blood Institute, Icahn School of Medicine at Mount Sinai
- ASAnna Simon
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Autoimmune Technologies (United States), National Heart Lung and Blood Institute
- RMRavikanth Maddipati
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Autoimmune Technologies (United States), National Heart Lung and Blood Institute
- MPMartin Pelletier
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Autoimmune Technologies (United States), National Heart Lung and Blood Institute
- HPHeiyoung Park
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Autoimmune Technologies (United States), National Heart Lung and Blood Institute
Topics & keywords
- Proinflammatory cytokine
- Mitochondrial ROS
- Reactive oxygen species
- NADPH oxidase
- Biology
- Tumor necrosis factor alpha
- Cell biology
- Inflammasome