Genomic inflation factors under polygenic inheritance
QIMR Berghofer Medical Research Institute · Peninsula College of Medicine and Dentistry · +20 more institutions
Abstract
Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide association studies (GWAS). Usually, the scaled median or mean test statistic for association calculated from multiple single-nucleotide-polymorphisms across the genome is used to assess such effects, and 'genomic control' can be applied subsequently to adjust test statistics at individual loci by a genomic inflation factor. Published GWAS have clearly shown that there are many loci underlying genetic variation for a wide range of complex diseases and traits, implying that a substantial proportion of the genome should show inflation of the test statistic. Here, we show by theory,…
Citation impact
- FWCI
- 16.83
- Percentile
- 100%
- References
- 25
Authors
21- JYJian YangCorresponding
QIMR Berghofer Medical Research Institute
- MNMichael N. Weedon
Peninsula College of Medicine and Dentistry, University of Exeter
- SPShaun Purcell
Massachusetts General Hospital, Broad Institute, Center for Human Genetics
- GLGuillaume Lettre
Montreal Heart Institute, Université de Montréal
- KEKarol Estrada
Rotterdam University of Applied Sciences
Topics & keywords
- Linkage disequilibrium
- Biology
- Genome-wide association study
- Population stratification
- Genetics
- Heritability
- Genetic association
- Population
- Decent work and economic growth