articleProceedings of the National Academy of SciencesMar 15, 2004GREEN OA

Human and avian influenza viruses target different cell types in cultures of human airway epithelium

MMMikhail MatrosovichTMTatyana MatrosovichTEThomas E. GrayNANoel A. RobertsHKHans‐Dieter Klenk

National Institute of Environmental Health Sciences · Roche (United Kingdom) · +3 more institutions

PubMed
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Abstract

The recent human infections caused by H5N1, H9N2, and H7N7 avian influenza viruses highlighted the continuous threat of new pathogenic influenza viruses emerging from a natural reservoir in birds. It is generally believed that replication of avian influenza viruses in humans is restricted by a poor fit of these viruses to cellular receptors and extracellular inhibitors in the human respiratory tract. However, detailed mechanisms of this restriction remain obscure. Here, using cultures of differentiated human airway epithelial cells, we demonstrated that influenza viruses enter the airway epithelium through specific target cells and that there were striking differences in this respect between human and avian…

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785
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Topics & keywords

Topics
Keywords
  • Biology
  • Virology
  • Influenza A virus subtype H5N1
  • Virus
  • Viral replication
  • Tropism
  • Tissue tropism
  • Respiratory epithelium
UN Sustainable Development Goals
  • Good health and well-being
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