Spontaneous Effort Causes Occult Pendelluft during Mechanical Ventilation
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · The University of Osaka · +4 more institutions
Abstract
To test the hypotheses that in injured lungs negative P(pl) generated by diaphragm contraction has localized effects (in dependent regions) that are not uniformly transmitted, and that such localized changes in P(pl) cause pendelluft.
We used electrical impedance tomography and dynamic computed tomography (CT) to analyze regional inflation in anesthetized pigs with lung injury. Changes in local P(pl) were measured in nondependent versus dependent regions using intrabronchial balloon catheters. The airway pressure needed to achieve comparable dependent lung inflation during paralysis versus spontaneous breathing was estimated. MEASUREMENTS AND MAIN RESULTS: In all animals, spontaneous breathing caused pendelluft during early inflation, which was associated with more negative local P(pl) in dependent regions versus nondependent regions (-13.0 ± 4.0 vs. -6.4 ± 3.8 cm H2O; P
Citation impact
- FWCI
- 13.80
- Percentile
- 100%
- References
- 31
Authors
10- TYTakeshi YoshidaCorresponding
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, The University of Osaka
- VTVinícius Torsani
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- SGSusimeire Gomes
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- RRRoberta Ribeiro De Santis Santiago
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- MAMarcelo A. Beraldo
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Topics & keywords
- Medicine
- Tidal volume
- Mechanical ventilation
- Ventilation (architecture)
- Lung
- Lung volumes
- Breathing
- Diaphragm (acoustics)