articleeLifeNov 13, 2012GOLD OA

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

HYHuan YanGZGuocai ZhongGXGuangwei XuWHWenhui HeZJZhiyi Jing

Peking University · National Institute of Biological Sciences, Beijing · +2 more institutions

PubMed
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Abstract

Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more severe disease. Cellular entry of both viruses is mediated by HBV envelope proteins. The pre-S1 domain of the large envelope protein is a key determinant for receptor(s) binding. However, the identity of the receptor(s) is unknown. Here, by using near zero distance photo-cross-linking and tandem affinity purification, we revealed that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver.…

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Topics & keywords

Topics
Keywords
  • Virology
  • Hepatitis B virus
  • Receptor
  • Viral entry
  • Biology
  • Hepatitis D virus
  • Virus
  • Gene silencing
UN Sustainable Development Goals
  • Good health and well-being
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