T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1

Dietary sugars are transported from the intestinal lumen into absorptive enterocytes by the sodium-dependent glucose transporter isoform 1 (SGLT1). Regulation of this protein is important for the provision of glucose to the body and avoidance of intestinal malabsorption. Although expression of SGLT1 is regulated by luminal monosaccharides, the luminal glucose sensor mediating this process was unknown. Here, we show that the sweet taste receptor subunit T1R3 and the taste G protein gustducin, expressed in enteroendocrine cells, underlie intestinal sugar sensing and regulation of SGLT1 mRNA and protein. Dietary sugar and artificial sweeteners increased SGLT1 mRNA and protein expression, and glucose absorptive…

• NS
  National Science Foundation

  Awards: 9724504, 1 S10 RR0 9145-01, DBI-9724504
• WT
  Wellcome Trust
• UO
  University of Liverpool
• UO
  University of Toronto
• NI
  National Institutes of Health

  Awards: 1 S10 RR0 9145-01, DC007399
• BA
  Banting and Best Diabetes Centre, University of Toronto
• R
  RIKEN
• NI
  National Institute on Deafness and Other Communication Disorders