Spatial organization of the extracellular matrix regulates cell–cell junction positioning
Centre National de la Recherche Scientifique · Université Joseph Fourier · +9 more institutions
Abstract
The organization of cells into epithelium depends on cell interaction with both the extracellular matrix (ECM) and adjacent cells. The role of cell-cell adhesion in the regulation of epithelial topology is well-described. ECM is better known to promote cell migration and provide a structural scaffold for cell anchoring, but its contribution to multicellular morphogenesis is less well-understood. We developed a minimal model system to investigate how ECM affects the spatial organization of intercellular junctions. Fibronectin micropatterns were used to constrain the location of cell-ECM adhesion. We found that ECM affects the degree of stability of intercellular junction positioning and the magnitude of intra-…
Citation impact
- FWCI
- 14.20
- Percentile
- 100%
- References
- 38
Authors
7- QTQingzong TsengCorresponding
Centre National de la Recherche Scientifique, Université Joseph Fourier, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, CEA Grenoble, Institut de Recherches en Technologies et Sciences pour le Vivant
- EDEve Duchemin-Pelletier
Inserm, Université Joseph Fourier, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, CEA Grenoble, Université Grenoble Alpes
- ADAlexandre Deshière
Inserm, Université Joseph Fourier, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, CEA Grenoble, Université Grenoble Alpes
- MBMartial Balland
Centre National de la Recherche Scientifique, Laboratoire Interdisciplinaire de Physique
- HGHervé Guillou
Centre National de la Recherche Scientifique, Tokyo University of Science, Université Joseph Fourier, Laboratory for Integrated Micro-Mechatronic Systems, Institut Néel
Topics & keywords
- Extracellular matrix
- Fibronectin
- Cell biology
- Morphogenesis
- Multicellular organism
- Intracellular
- Cell junction
- Cell adhesion