Fabrication of Pulsatile Cardiac Tissue Grafts Using a Novel 3-Dimensional Cell Sheet Manipulation Technique and Temperature-Responsive Cell Culture Surfaces
Waseda University · Tokyo Women's Medical University
Abstract
Recent progress in cell transplantation therapy to repair impaired hearts has encouraged further attempts to bioengineer 3-dimensional (3-D) heart tissue from cultured cardiomyocytes. Cardiac tissue engineering is currently pursued utilizing conventional technology to fabricate 3-D biodegradable scaffolds as a temporary extracellular matrix. By contrast, new methods are now described to fabricate pulsatile cardiac grafts using new technology that layers cell sheets 3-dimensionally. We apply novel cell culture surfaces grafted with temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm), from which confluent cells detach as a cell sheet simply by reducing temperature without any enzymatic…
Citation impact
- FWCI
- 30.49
- Percentile
- 100%
- References
- 38
Authors
9- TSTatsuya ShimizuCorresponding
Waseda University, Tokyo Women's Medical University
- MYMasayuki Yamato
Waseda University, Tokyo Women's Medical University
- YIYuki Isoi
Waseda University, Tokyo Women's Medical University
- TATakumitsu Akutsu
Waseda University, Tokyo Women's Medical University
- TSTakeshi Setomaru
Waseda University, Tokyo Women's Medical University
Topics & keywords
- Transplantation
- Pulsatile flow
- Tissue engineering
- Extracellular matrix
- Biomedical engineering
- In vivo
- Connective tissue
- Cell culture