MicroRNAs in NF- B signaling

Nuclear factor κB (NF-κB) is a transcriptional factor that regulates a battery of genes that are critical to innate and adaptive immunity, cell proliferation, inflammation, and tumor development. MicroRNAs (miRNAs) are short RNA molecules of 20-25 nucleotides in length that negatively regulate gene expression in animals and plants primarily by targeting 3' untranslated regions of mRNAs. In this work, we review the convergence of miRNAs and NF-κB signaling and dysregulation of miRNAs and NF-κB activation in human diseases, particularly in cancer. The function of miR-146, miR-155, miR-181b, miR-21, and miR-301a in NF-κB activation and their impact on tumorigenesis are discussed. Given that over 1000 human miRNAs…

• AH
  American Heart Association
• UO
  University of Louisville

  Awards: ES014443, RR024489
• NI
  National Institutes of Health

  Awards: RR024489, CA138688, ES014443, P20 RR024489, P30 ES014443
• NI
  National Institute of Environmental Health Sciences

  Award: ES014443
• NC
  National Center for Research Resources

  Award: RR024489