Mobility of Plasmids
Centre National de la Recherche Scientifique · Institut Pasteur · +4 more institutions
Abstract
Plasmids are key vectors of horizontal gene transfer and essential genetic engineering tools. They code for genes involved in many aspects of microbial biology, including detoxication, virulence, ecological interactions, and antibiotic resistance. While many studies have decorticated the mechanisms of mobility in model plasmids, the identification and characterization of plasmid mobility from genome data are unexplored. By reviewing the available data and literature, we established a computational protocol to identify and classify conjugation and mobilization genetic modules in 1,730 plasmids. This allowed the accurate classification of proteobacterial conjugative or mobilizable systems in a combination of…
Citation impact
- FWCI
- 15.92
- Percentile
- 100%
- References
- 156
Authors
5- CSChristopher S. SmillieCorresponding
Centre National de la Recherche Scientifique, Institut Pasteur, Sorbonne Université
- MPM. Pilar Garcillán‐Barcia
Universidad de Cantabria, Instituto de Biomedicina y Biotecnología de Cantabria
- MVMaría Victoria Francia
Instituto de Investigación Marqués de Valdecilla
- EPEduardo P. C. Rocha
Centre National de la Recherche Scientifique, Institut Pasteur, Sorbonne Université
- FDFernando de la Cruz
Universidad de Cantabria, Instituto de Biomedicina y Biotecnología de Cantabria
Topics & keywords
- Plasmid
- Biology
- Horizontal gene transfer
- Genetics
- Mobile genetic elements
- Gene
- Genome
- Bacterial conjugation