Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes
National Jewish Health · University of Colorado Health · +5 more institutions
Abstract
Atopic dermatitis (AD) and psoriasis are the two most common chronic skin diseases. However patients with AD, but not psoriasis, suffer from frequent skin infections. To understand the molecular basis for this phenomenon, skin biopsies from AD and psoriasis patients were analyzed using GeneChip microarrays. The expression of innate immune response genes, human beta defensin (HBD)-2, IL-8, and inducible NO synthetase (iNOS) was found to be decreased in AD, as compared with psoriasis, skin (HBD-2, p = 0.00021; IL-8, p = 0.044; iNOS, p = 0.016). Decreased expression of the novel antimicrobial peptide, HBD-3, was demonstrated at the mRNA level by real-time PCR (p = 0.0002) and at the protein level by…
Citation impact
- FWCI
- 44.38
- Percentile
- 100%
- References
- 46
Authors
11- INIchiro NomuraCorresponding
National Jewish Health, University of Colorado Health, University of Colorado Denver
- EGElena Goleva
National Jewish Health, University of Colorado Health, University of Colorado Denver
- MHMichael Howell
National Jewish Health, University of Colorado Health, University of Colorado Denver
- QHQ Hamid
Christie (Canada), McGill University
- PYPeck Y. Ong
National Jewish Health, University of Colorado Health, University of Colorado Denver
Topics & keywords
- Psoriasis
- Immunology
- Proinflammatory cytokine
- Innate immune system
- Atopic dermatitis
- Immune system
- Antimicrobial peptides
- Cytokine
- Good health and well-being