articleJAMAMar 6, 2012HYBRID OA

Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy

JEJerome Engel

University of California, Los Angeles

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Abstract

ContextDespite reported success, surgery for pharmacoresistant seizures is often seen as a last resort. Patients are typically referred for surgery after 20 years of seizures, often too late to avoid significant disability and premature death.ObjectiveWe sought to determine whether surgery soon after failure of 2 antiepileptic drug (AED) trials is superior to continued medical management in controlling seizures and improving quality of life (QOL).Design, Setting, and ParticipantsThe Early Randomized Surgical Epilepsy Trial (ERSET) is a multicenter, controlled, parallel-group clinical trial performed at 16 US epilepsy surgery centers. The 38 participants (18 men and 20 women; aged ≥12 years) had mesial temporal…

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Topics & keywords

Topics
Keywords
  • Medicine
  • Epilepsy
  • Randomized controlled trial
  • Epilepsy surgery
  • Quality of life (healthcare)
  • Drug Resistant Epilepsy
  • Pediatrics
  • Clinical trial
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