On the lag phase in amyloid fibril formation

The formation of nanoscale amyloid fibrils from normally soluble peptides and proteins is a common form of self-assembly phenomenon that has fundamental connections with biological functions and human diseases. The kinetics of this process has been widely studied and exhibits on a macroscopic level three characteristic stages: a lag phase, a growth phase and a final plateau regime. The question of which molecular events take place during each one of these phases has been a central element in the quest for a mechanism of amyloid formation. In this review, we discuss the nature and molecular origin of the lag-phase in amyloid formation by making use of tools and concepts from physical chemistry, in particular…

• FA
  Frances and Augustus Newman Foundation
• LU
  Lunds Universitet
• V
  Vetenskapsrådet
• BA
  Biotechnology and Biological Sciences Research Council

  Award: BB/J002119/1