Developmental and Hormonally Regulated Messenger Ribonucleic Acid Expression of KiSS-1 and Its Putative Receptor, GPR54, in Rat Hypothalamus and Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide
University of Córdoba · Universidade de Santiago de Compostela
Abstract
The gonadotropic axis is centrally controlled by a complex regulatory network of excitatory and inhibitory signals that is activated at puberty. Recently, loss of function mutations of the gene encoding G protein-coupled receptor 54 (GPR54), the putative receptor for the KiSS-1-derived peptide metastin, have been associated with lack of puberty onset and hypogonadotropic hypogonadism. Yet the pattern of expression and functional role of the KiSS-1/GPR54 system in the rat hypothalamus remain unexplored to date. In the present work, expression analyses of KiSS-1 and GPR54 genes were conducted in different physiological and experimental settings, and the effects of central administration of KiSS-1 peptide on LH…
Citation impact
- FWCI
- 39.97
- Percentile
- 100%
- References
- 26
Authors
10Topics & keywords
- Endocrinology
- Internal medicine
- Kisspeptin
- Biology
- Hypothalamus
- Hypogonadotropic hypogonadism
- Estrous cycle
- Receptor
- Good health and well-being