Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms
Emory University · Augenstern · +2 more institutions
Abstract
It is well known that inflammatory conditions of the intestinal mucosa result in compromised barrier function. Inflammation is characterized by an influx into the mucosa of immune cells that influence epithelial function by releasing proinflammatory cytokines such as IFN-gamma and TNF-alpha. Mucosal barrier function is regulated by the epithelial apical junctional complex (AJC) consisting of the tight junction and the adherens junction. Since the AJC regulates barrier function, we analyzed the influence of IFN-gamma and TNF-alpha on its structure/function and determined the contribution of apoptosis to this process using a model intestinal epithelial cell line, T84, and IFN-gamma and TNF-alpha. AJC…
Citation impact
- FWCI
- 25.18
- Percentile
- 100%
- References
- 72
Authors
7Topics & keywords
- Barrier function
- Proinflammatory cytokine
- Cell biology
- Occludin
- Tight junction
- Adherens junction
- Cell junction
- Cytokine