articleNew England Journal of MedicineJul 30, 2014BRONZE OA

Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009

Boston Children's Hospital · Dana-Farber Cancer Institute · +38 more institutions

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Abstract

Background

The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diagnosed at birth.

Methods

We collected data retrospectively from 240 infants with SCID who had received transplants at 25 centers during a 10-year period (2000 through 2009).

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